Weekly Brief, 22 July 2024

This week's highlights

ELIXIR in the next Genome BC Data Literacy series

23 September 2024 | 18:30 - 19:30 CEST

In the next Genome BC Data Literacy series, Tim Hubbard, the ELIXIR Director, will present how ELIXIRs innovative initiatives foster collaboration and drive scientific breakthroughs.

More information and registration

Recommended reads

Harnessing hyperthermia: molecular, cellular, and immunological insights for enhanced anticancer therapies

An ELIXIR-HU paper

This review focuses on 2 key aspects of hyperthermia: its molecular and cellular effects and its impact on the immune system. Mild systemic hyperthermia mimics fever, activating immune cells and raising metabolic rates. Intense heat above 50C can release tumour antigens, enhancing immune reactions. Using photothermal nanoparticles for targeted heating and drug delivery can also modulate the immune response. Hyperthermia emerges as a cost-effective and well-tolerated adjuvant therapy when integrated with immunotherapy. This review serves as a valuable resource for the selection of patient-specific treatments and the guidance of future experimental studies.

Read more

EpiSegMix: a flexible distribution hidden Markov model with duration modeling for chromatin state discovery

An ELIXIR-DE paper

Automated chromatin segmentation based on ChIP-seq data reveals insights into the epigenetic regulation of chromatin accessibility. Existing segmentation methods are constrained by simplifying modeling assumptions, which may have a negative impact on the segmentation quality. This paper introduces EpiSegMix, a novel segmentation method based on a hidden Markov model with flexible read count distribution types and state duration modeling, allowing for a more flexible modeling of both histone signals and segment lengths. Its flexible framework enables it to fit an accurate probabilistic model, which has the potential to increase the biological interpretability of chromatin states.

Read more

Updates from Nodes

Europe PMC API workshop for ELIXIR - Part 1

7 August 2024 | 14:00 - 15:00 CEST | Online

The workshop is tailored specifically for ELIXIR colleagues who wish to integrate and reuse developer tools from Europe PMC. The workshop series will cover case studies demonstrating the use of Articles API, Annotations APIs, bulk download options, and advanced search syntax. Details of the second workshop will be announced in September.

Register now

Updates from Platforms

RDMkit Club meeting

25 July 2024 | 10:00 CEST

RDMkit Club is an informal drop-in session held on the last Thursday of each month. The participants come together to discuss all topics related to RDMkit including its impact and future directions. The Club is open to everybody within and beyond ELIXIR.

More information and registration

Updates from Communities

ELIXIR Federated Human Data Community day

19 November 2024 | Lisbon, Portugal

The ELIXIR Federated Human Data Community day aims to bring together members of the ELIXIR FHD Community to share ideas, update on relevant projects happening across Europe and internationally and provide professional networking time around FHD-related special topics.

More information and registration

Updates from other initiatives

Training workshop - From zero to hero with Python

17 - 18 October 2024 | Online

This workshop will cover all basic concepts needed to program in Python3 and demonstrate how to showcase code and its results on a website.

More information and registration

GA4GH 12th Plenary

16 - 20 September 2024 | Melbourne, Australia

GA4GH 12th Plenary brings together organisations and initiatives from the genomics and health community for keynotes, talks, and workshops. The conference will focus on genomic and clinical data sharing issues that pervade diverse industries, disciplines, and communities.

More information

GDI National Genomic Plans workshop recordings are now available online

In June 2024, the GDI project held an online workshop Towards the Implementation of National Genomic Plans in EU countries". The workshop recordings are now available as a YouTube playlist and on the 1+MG Framework website.

Check the recordings

Upcoming ELIXIR events & webinars

ELIXIR Training Courses & Webinars

The ELIXIR TeSS portal has a variety of interesting events and courses organised by the ELIXIR Nodes. For more, visit TeSS portal

ELIXIR Events and Conferences

ECCB 2024
16 - 20 September 2024 | Turku, Finland

ELIXIR Single-Cell Omics Community meeting
16 - 17 September 2024 | Helsinki, Finland

ELIXIR Data Platform F2F 2024
1 - 2 October 2024 | Padova, Italy

ELIXIR STEERS WP2 & WP3 workshop
2 - 3 October 2024 | Padova, Italy

BioHackathon Europe 2024
4 - 8 November 2024 | Barcelona, Spain

Job vacancies

All vacancies are also published on the ELIXIR website (also including those from industry). If you need our help communicating your new open positions, you can submit a job advertisement and it will automatically appear on our newsletters. Go to our vacancy page to submit a job
 

Research Engineer for Infrastructure in Health Data Projects (RE1/RE2)

Barcelona Supercomputing Center (BSC), coordinators of INB/ELIXIR-ES

EC Project Manager

ELIXIR

Junior Professorship in AI and Multiscale Modeling in Biology and Bio-medicine

University of Montpellier / CNRS / INSERM

Group Leader (rank Director)

SIB Swiss Institute of Bioinformatics