3D-BioInfo Community webinar series

Uncovering new families and folds in the natural protein universeStructural bioinformatics provides methods and tools to analyse, predict, archive and validate the three-dimensional (3D) structure data of biomacromolecules such as proteins, RNA or DNA.

The specific 3D shapes of macromolecules allow them to perform many functions within cells. Understanding their structures is therefore crucial for understanding the interactions and functions of cells, which in turn opens up potential for innovations in biotechnology and drug development.

The 3D-BioInfo Community is concerned with improving the ontologies and validation tools for enabling better integration of the data and methods for analysing and predicting protein structures and their complexes. Part of this work is presented in an ongoing series of webinars:

FAIR Infrastructure for protein structural and functional annotations
Open Resources for sharing, integrating and benchmarking software tools for modelling the Interactome in 3D
Development of models for protein-ligand interactions
Protein Engineering
Assessment of large scale applications of Alphafold2 in structural bioinformatics
In Silico screen of protein-protein interactions
Machine learning for reconstructing dynamic protein structures from cryo-EM images
AlphaFold changes everything (and nothing)
Addressing the void between protein sequence and structure
Cryo-EM and artificial intelligence: A marriage made in cellular fractions
Harnessing protein folding neural networks for peptide-protein docking: what have we learned
Computer Aided Drugs Design (CADD)
Causes and Consequences of Epistasis in Protein Evolution and Design
New Era of Structure Abundance - Insights into Protein Function
Protein Engineering And Design 2024

FAIR Infrastructure for protein structural and functional annotations (3D-BioInfo Activity I)

29 June 2021 15:00 CEST

Programme

Overview of the 3D-Beacons project by Sameer Velankar (PDBe at EBI)
3D-Beacons client and API by Ian Sillitoe (UCL)
Model quality by Gerardo Tauriello (SIB)

For links to the slides and for other details please see the event page.

Open Resources for sharing, integrating and benchmarking software tools for modelling the Interactome in 3D (3D-BioInfo Activity II)

21 September 2021 15:00 CEST

Programme

A community-wide effort to improve annotations and organize information on macromolecular assemblies in the PDB by Shoshana Wodak (VIB-VUB, ELIXIR-BE)
Benchmark datasets of physiological and non-physiological protein assemblies, derived using the QSBio and ProtCID resources for structural information on protein assemblies by Emmanuel Levy (Weizmann Institute, ELIXIR-IL) & Roland Dunbrack (Temple University)(UCL)
Performance of classifiers & scoring methods in discriminating between physiological and non-physiological protein interfaces (work in progress) by Hugo Schweke (Weizmann Institute, ELIXIR-IL)

For links to the slides and for other details please see the event page.

Development of models for protein-ligand interactions (3D-BioInfo Activity III)

19 October 2021 15:00 CEST

Programme

Development of models for protein-ligand interactions by Vincent Zoete (SIB, ELIXIR-CH)
Development of reliable Benchmark Sets for Structure-Based Drug Designby by Ute Röhrig (UNIL, ELIXIR-CH)

For links to the slides and for other details please see the event page.

Protein Engineering

15 February 2022 15:00 CEST

Programme

Introduction and overview Lynne Regan (University of Edinburgh, UK)
Web-based tools for computational enzyme design by David Bednář (Masaryk University, Czech Republic)
Computational ranking of protein designs: comparison with experiment by Christopher W. Wood (University of Edinburgh, UK)
Engineering Enzyme Replacement Therapies using Generative Deep Learning by Giovanni Stracquadanio (University of Edinburgh, UK)

For links to the slides and for other details please see the event page.